A potent mix for creating elegant mobile applications is Kendo UI Mobile with MVVM and RequireJS. Included is an online sandbox environment with code snippets that will highlight the concepts needed to create more advanced Kendo UI Mobile applications. This has been created using jsFiddle and acts as a starter template to update or fork as needed.
If you are a big believer in Kendo UI, then you will be glad to know there is a built-in template engine as well. The problem was that you have to load the entire kendo.web.min.js file just to render a simple template (~0.5MB). Kendo is now AMD-complaint and can be used with RequireJS! I can now use Kendo UI’s as my new favorite template engine. Why not if I plan to use other parts of the Kendo suite later or on other pages.
When working with existing sites or content management systems, you have little say on where and when jQuery is loaded. To complicate matters, some pages may have jQuery auto-loaded, and others may not (yay for performance boosts, nay for client-side plugins). Do you bite the bullet and write unmanageable scripts? Or do you believe in RequireJS and dodge the bullet matrix-style?